2-Chloro-6-methylpyridine

CAS No. 18368-63-3
Cat. No. CS-W001993
Purity≥97%
MDL No.MFCD00006245

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 18368-63-3

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Description

2-Chloro-6-methylpyridine is a bench-stable, electron-deficient heterocycle featuring a chlorine atom at the 2-position and a methyl group at the 6-position. This regioselective substitution pattern enables direct functionalization in cross-coupling reactions, facilitating efficient access to complex pyridyl architectures in medicinal chemistry and agrochemical synthesis.

Application

2-Chloro-6-methylpyridine serves as a versatile building block in synthetic organic chemistry, enabling palladium-catalyzed cross-coupling reactions due to its well-established reactivity at the chlorine site. The methyl group provides a handle for further functionalization, while the pyridine core offers favorable electronic properties for heterocyclic scaffold construction. Its bench stability and compatibility with standard reaction conditions make it a reliable choice for medicinal chemistry and process development workflows.

General Information

CAS No. 18368-63-3
Cat. No. CS-W001993
Purity ≥97%
MDL No. MFCD00006245
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₆ClN
Molecular Weight 127.57
Synonym(s) 6-Chloro-2-picoline
SMILES CC1=NC(Cl)=CC=C1

Computational Chemistry Data

TPSA 12.89
LogP 2.04342
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H227-H315-H319-H335
Precautionary Statements : P210-P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P370+P378-P403-P405-P501

Quality Control

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Other Classifications

Bioactive Molecules Dye and Bio-assay Reagents

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Chloro-6-methylpyridine

CAS No. 18368-63-3

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