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2-Methyl-3,4,10,14b-tetrahydrobenzo[c]pyrazino[1,2-a]pyrido[3,2-f]azepin-1(2H)-one Mirtazapine Impurity

  • CAS No. 191546-96-0

  • Cat. No. CS-0532806
  • Molecule weight279.34
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Methyl-3,4,10,14b-tetrahydrobenzo[c]pyrazino[1,2-a]pyrido[3,2-f]azepin-1(2H)-one Mirtazapine Impurity|CS-0532806

Structure of 191546-96-0

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General Information

  • CAS No. 191546-96-0
  • Cat. No. CS-0532806
  • Purity ≥98%
  • MDL No. None
  • Storage Sealed in dry,2-8℃
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₇H₁₇N₃O
  • Molecular Weight 279.34
  • Synonym(s) 1-Oxo Mirtazapine (Mirtazapine Impurity C)
  • SMILES O=C1N(CCN2C3=NC=CC=C3CC4=C(C12)C=CC=C4)C

Description

Amodiaquine (AQ) is currently used in combination with Artesunate (AS) as first-line treatment for some cases of falciparum malaria (UM) in many countries. AQ is metabolized by hepatic cytochrome P450 2C8 (CYP2C8) to Desethylamodiaquine (DAQ; DEAQ; NADQ; Ndes-amo), which is subsequently eliminated via extra-hepatic biotransformation by CYP1A1 and CYP1B1. DEAQ is responsible for the pharmacological activity of AQ (both therapeutic and toxicity) due to its long elimination half-life.

Synthesis

  • Route1
    • null|null
      1071504-87-4
    • ~13%
    • 2-Methyl-3,4,10,14b-tetrahydrobenzo[c]pyrazino[1,2-a]pyrido[3,2-f]azepin-1(2H)-one Mirtazapine Impurity|CS-0532806
      191546-96-0

    References

    • N.V. Organon Patent: US2008/255349 A1, 2008 ; Location in patent: Page/Page column 9 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07,GHS09
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H411
Precautionary Statements : P264-P270-P273-P330-P391-P501

Quality Control

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Computational Chemistry Data

  • TPSA   36.44
  • LogP   2.0055
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

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