(R)-(1-Methylazetidin-2-yl)methanol

CAS No. 1932543-77-5
Cat. No. CS-0172773
Purity≥98%
MDL No.None

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(R)-(1-Methylazetidin-2-yl)methanol|CS-0172773

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General Information

CAS No. 1932543-77-5
Cat. No. CS-0172773
Purity ≥98%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₁₁NO
Molecular Weight 101.15
Synonym(s) (R)-(1-Methyl-azetidin-2-yl)-methanol
SMILES C(O)[C@@H]1N(C)CC1

Description

(R)-(1-Methylazetidin-2-yl)methanol is a chiral building block featuring a strained four-membered azetidine ring with a methylated nitrogen and a primary alcohol at the 2-position. This configuration imparts enhanced solubility and metabolic stability, enabling efficient incorporation into bioactive molecules. The stereochemistry supports high diastereoselectivity in coupling reactions, making it valuable for medicinal chemistry applications requiring precise spatial control.

Application

(R)-(1-Methylazetidin-2-yl)methanol serves as a versatile chiral building block in medicinal chemistry, enabling efficient access to bioactive azetidine-containing scaffolds. Its bench-stable nature and compatibility with standard coupling and functionalization protocols facilitate straightforward incorporation into drug candidates. The molecule functions effectively in amide bond formation, reductive amination, and transition-metal-catalyzed transformations, supporting scalable synthesis and purification workflows common in API development.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 23.47
LogP -0.3172
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Aliphatic heterocycle compounds Azetidine compounds

Key Words

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(R)-(1-Methylazetidin-2-yl)methanol

CAS No. 1932543-77-5

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