3-Chloro-2-naphthoic acid

CAS No. 19411-56-4
Cat. No. CS-0567084
Purity≥95%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 19411-56-4
Cat. No. CS-0567084
Purity ≥95%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₇ClO₂
Molecular Weight 206.63
Synonym(s) 3-Chloronaphthalene-2-carboxylic acid
SMILES O=C(C1=C(Cl)C=C2C=CC=CC2=C1)O

Description

3-Chloro-2-naphthoic acid features a chlorinated naphthalene core with a carboxylic acid group at the 2-position, offering enhanced electron-withdrawal and reactivity. This structural motif enables direct incorporation into pharmaceutical intermediates and functionalized polymers under standard conditions. The compound exhibits robust stability and facilitates efficient coupling reactions in synthetic workflows.

Application

3-Chloro-2-naphthoic acid serves as a versatile building block in the synthesis of pharmaceutical intermediates and functionalized heterocycles. Its naphthoic acid core provides a rigid, planar scaffold with enhanced electrophilicity at the C3 position due to the ortho-chloro substituent. The carboxylic acid group enables direct derivatization via esterification, amide formation, or decarboxylative coupling. Bench-stable and readily purified by recrystallization, it facilitates efficient access to bioactive scaffolds through established transition-metal-catalyzed transformations.

Synthesis

Route1
- In-stock
  
  5959-52-4
- ~%
- In-stock
  
  19411-56-4
References
- NOVARTIS AG; NOVARTIS PHARMA GMBH Patent: WO2004/48314 A1, 2004 ; Location in patent: Page 39-40 ;
Route2
- 92-70-6
- ~%
- In-stock
  
  19411-56-4
References
- National University Corporation Okayama University Patent: US7928236 B2, 2011 ; Location in patent: Page/Page column 7-8 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 37.3
LogP 3.1914
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aromatic ring compounds Naphthalene compounds

Key Words

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3-Chloro-2-naphthoic acid

CAS No. 19411-56-4

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