(Tetrahydro-2H-pyran-4-yl)hydrazine hydrochloride

CAS No. 194543-22-1
Cat. No. CS-0047579
Molecule weight152.62
Purity≥97%
MDL No.MFCD09744677

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(Tetrahydro-2H-pyran-4-yl)hydrazine hydrochloride|CS-0047579

Structure of 194543-22-1

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General Information

CAS No. 194543-22-1
Cat. No. CS-0047579
Purity ≥97%
MDL No. MFCD09744677
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₁₃ClN₂O
Molecular Weight 152.62
Synonym(s) 4-Hydrazinyltetrahydropyran Hydrochloride
SMILES NNC1CCOCC1.[H]Cl

Description

Tetrahydro-2H-pyran-4-yl)hydrazine hydrochloride delivers a stable, moisture-tolerant hydrazine handle for conjugation and functionalization. The tetrahydropyran ring imparts solubility and metabolic stability, while the hydrazinium moiety enables selective coupling reactions under mild conditions. This reagent streamlines access to hydrazone-linked architectures in synthetic and medicinal chemistry workflows.

Application

(Tetrahydro-2H-pyran-4-yl)hydrazine hydrochloride serves as a stable, bench-ready hydrazine equivalent for the construction of pyran-based heterocycles and hydrazide derivatives. Its tetrahydropyranyl protecting group enables orthogonal handling in complex syntheses, while the hydrazine moiety facilitates reliable condensation reactions with carbonyl compounds, enabling access to diverse hydrazone scaffolds under mild conditions.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 47.28
LogP 0.0505
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Tetrahydropyran compounds

Key Words

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(Tetrahydro-2H-pyran-4-yl)hydrazine hydrochloride

CAS No. 194543-22-1

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