DMT-OMe-rC(Ac)

CAS No. 199593-08-3
Cat. No. CS-0172019
Purity≥97%
MDL No.MFCD08704192

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Description

DMT-OMe-rC(Ac) is a protected ribocytidine derivative featuring a dimethoxytrityl (DMT) group at the 5′-OH and an acetyl moiety on the N4-amino function. This configuration enables orthogonal protection during oligonucleotide synthesis, offering enhanced stability and controlled deprotection sequences for efficient incorporation into RNA strands.

Application

DMT-OMe-rC(Ac) serves as a versatile phosphoramidite building block for solid-phase oligonucleotide synthesis, enabling the incorporation of acetylated 2'-deoxyribofuranosyl cytidine residues with high fidelity. The dimethoxytrityl (DMT) group provides robust protection and convenient monitoring via UV detection, while the OMe and Ac modifications enhance nucleoside stability and modulate hybridization properties. This derivative facilitates efficient coupling and selective deprotection, supporting reliable synthesis of modified DNA strands for research and diagnostic applications.

General Information

CAS No. 199593-08-3
Cat. No. CS-0172019
Purity ≥97%
MDL No. MFCD08704192
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₃₃H₃₅N₃O₈
Molecular Weight 601.65
Synonym(s) N-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methylcytidine
SMILES O[C@H]1[C@@H](OC)[C@H](N2C(N=C(NC(C)=O)C=C2)=O)O[C@@H]1COC(C3=CC=C(OC)C=C3)(C4=CC=C(OC)C=C4)C5=CC=CC=C5

Computational Chemistry Data

TPSA 130.37
LogP 3.5009
H_Acceptors 10
H_Donors 2
Rotatable_Bonds 11

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H320-H335
Precautionary Statements : P261-P280-P302+P352

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Other Classifications

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Nucleosides & Nucleotides 5'-Protected Nucleosides

Chemical Biology Nucleic Acid Chemistry Protected Nucleosides

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleobases and their Analogs

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleoside Analogs

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleosides

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DMT-OMe-rC(Ac)

CAS No. 199593-08-3

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