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CS-W001157 4
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2-(3-(But-3-yn-1-yl)-3H-diazirin-3-yl)acetic acid

  • CAS No. 2049109-24-0

  • Cat. No. CS-0196970
  • Purity≥95%
  • MDL No.MFCD31922730
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2-(3-(But-3-yn-1-yl)-3H-diazirin-3-yl)acetic acid|CS-0196970

Structure of 2049109-24-0

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Description

This diazirine-functionalized acetic acid derivative enables site-specific photoaffinity labeling under mild conditions. The butynyl linker provides metabolic stability and facilitates conjugation via copper-catalyzed alkyne-azide cycloaddition, while the photoreactive diazirinyl group integrates efficiently into biomolecular targets upon UV irradiation.

Application

2-(3-(But-3-yn-1-yl)-3H-diazirin-3-yl)acetic acid serves as a versatile photoaffinity labeling probe, enabling site-specific covalent capture of interacting biomolecules upon UV irradiation. The diazirine ring exhibits high thermal stability and reacts efficiently with adjacent C–H bonds, while the butynyl linker provides compatibility with copper-catalyzed azide-alkyne cycloaddition (CuAAC) for conjugation. This bifunctional architecture facilitates modular probe design and purification via standard chromatographic methods, making it well-suited for target identification in drug discovery workflows.

General Information

  • CAS No. 2049109-24-0
  • Cat. No. CS-0196970
  • Purity ≥95%
  • MDL No. MFCD31922730
  • Storage -20°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈N₂O₂
  • Molecular Weight 152.15
  • Synonym(s) Diazirine-acid
  • SMILES O=C(O)CC1(N=N1)CCC#C

Computational Chemistry Data

  • TPSA   62.02
  • LogP   1.0366
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   4

Safety Information

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GHS Pictogram :
GHS No : GHS02,GHS05
Signal Word : Danger
UN#: 2924
Class : 3,8
Packing Group :
Hazard Statements : H226-H314
Precautionary Statements : P210-P240-P242-P243-P264-P271-P280-P301+P330+P331-P304+P340-P363-P370+P378-P501

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