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CS-W001157 4
Total: USD 88.00

5-Iodobenzo[b]thiophene

  • CAS No. 20532-38-1

  • Cat. No. CS-0438157
  • Molecule weight260.09
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Iodobenzo[b]thiophene|CS-0438157

Structure of 20532-38-1

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General Information

  • CAS No. 20532-38-1
  • Cat. No. CS-0438157
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅IS
  • Molecular Weight 260.09
  • Synonym(s) 5-IODO-BENZO[B]-THIOPHENE
  • SMILES IC1=CC2=C(SC=C2)C=C1

Description

5-Iodobenzo[b]thiophene offers a robust, bench-stable platform for cross-coupling reactions, featuring a reactive iodine handle at the 5-position. The fused thiophene ring imparts electron-rich character, enhancing compatibility in palladium-catalyzed transformations. This structure enables efficient integration into complex heterocyclic architectures and functional materials.

Application

5-Iodobenzo[b]thiophene serves as a versatile building block in transition-metal-catalyzed cross-coupling reactions, enabling efficient construction of biaryl and heteroaryl architectures. The iodine substituent facilitates reliable Suzuki, Stille, and Negishi couplings under standard conditions, while the benzo[b]thiophene core offers enhanced stability and orthogonal reactivity for downstream functionalization. Its bench-stable nature and compatibility with diverse reaction conditions make it a practical choice for medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   0
  • LogP   3.5059
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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