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CS-W001157 4
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4-Fluoroaniline Hydrochloride

  • CAS No. 2146-07-8

  • Cat. No. CS-0214106
  • Molecule weight147.58
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Fluoroaniline Hydrochloride|CS-0214106

Structure of 2146-07-8

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General Information

  • CAS No. 2146-07-8
  • Cat. No. CS-0214106
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇ClFN
  • Molecular Weight 147.58
  • Synonym(s) 4-Fluorophenylammonium Chloride
  • SMILES NC1=CC=C(C=C1)F.[H]Cl

Description

4-Fluoroaniline Hydrochloride offers a stable, moisture-tolerant form of the electron-rich aromatic amine, enabling reliable incorporation into pharmaceutical intermediates and functional materials. The para-fluorinated scaffold enhances metabolic stability and modulates electronic properties in synthetic applications.

Application

4-Fluoroaniline Hydrochloride serves as a key building block in the synthesis of pharmaceutical intermediates and agrochemicals. Its aniline functionality enables direct coupling reactions, while the fluorine substituent imparts metabolic stability and modulates electronic properties. The hydrochloride salt enhances solubility and handling stability, facilitating straightforward purification and use in standard amide couplings, electrophilic substitutions, and Suzuki-Miyaura cross-coupling protocols.

Synthesis

  • Route1

    References

    • De Noronha, Rita G.; Romao, Carlos C.; Fernandes, Ana C. Journal of Organic Chemistry, 2009 , vol. 74, # 18 p. 6960 - 6964
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      4-Fluoroaniline Hydrochloride|CS-0214106
      2146-07-8

    References

    • Gill, Rupinder Kaur; Singh, Gagandeep; Sharma, Anuradha; Bedi; Saxena Medicinal Chemistry Research, 2013 , vol. 22, # 9 p. 4211 - 4222

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   1.8297
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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