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Methyl 6-bromo-[1,2,4]triazolo[4,3-a]pyridine-8-carboxylate

  • CAS No. 2349371-98-6

  • Cat. No. CS-0094755
  • Molecule weight256.06
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Methyl 6-bromo-[1,2,4]triazolo[4,3-a]pyridine-8-carboxylate|CS-0094755

Structure of 2349371-98-6

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General Information

  • CAS No. 2349371-98-6
  • Cat. No. CS-0094755
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆BrN₃O₂
  • Molecular Weight 256.06
  • Synonym(s) None
  • SMILES BrC(C=C1C(OC)=O)=CN2C1=NN=C2

Description

Methyl 6-bromo-[1,2,4]triazolo[4,3-a]pyridine-8-carboxylate is a heterocyclic building block featuring a brominated triazolopyridine core paired with a methyl ester handle. This scaffold integrates readily into cross-coupling reactions and offers enhanced stability under standard conditions. The electron-deficient triazole ring enables selective functionalization in medicinal chemistry and materials synthesis workflows.

Application

Methyl 6-bromo-[1,2,4]triazolo[4,3-a]pyridine-8-carboxylate serves as a versatile heterocyclic building block for medicinal chemistry and process development. The bromo group enables palladium-catalyzed cross-coupling reactions, while the ester functionality supports further derivatization. Its stability under standard reaction conditions and compatibility with diverse functional groups facilitate efficient synthesis of triazolopyridine-based scaffolds relevant to kinase inhibitors and other bioactive molecules.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

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Computational Chemistry Data

  • TPSA   56.49
  • LogP   1.2784
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   1

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