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CS-W001157 4
Total: USD 88.00

((2-Fluoro-6-(methoxymethoxy)-8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)naphthalen-1-yl)ethynyl)triisopropylsilane

  • CAS No. 2621932-37-2

  • Cat. No. CS-0159787
  • Molecule weight512.54
  • Purity≥96%
  • MDL No.MFCD34566906

*For research and further manufacturing use only, not for direct human use.

((2-Fluoro-6-(methoxymethoxy)-8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)naphthalen-1-yl)ethynyl)triisopropylsilane|CS-0159787

Structure of 2621932-37-2

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General Information

  • CAS No. 2621932-37-2
  • Cat. No. CS-0159787
  • Purity ≥96%
  • MDL No. MFCD34566906
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₉H₄₂BFO₄Si
  • Molecular Weight 512.54
  • Synonym(s) None
  • SMILES FC(C=CC1=CC(OCOC)=CC(B2OC(C)(C)C(C)(C)O2)=C13)=C3C#C[Si](C(C)C)(C(C)C)C(C)C

Description

This naphthalene-based boronate ester features a triisopropylsilyl-protected alkyne, enabling stable, selective coupling in palladium-catalyzed cross-coupling reactions. The methoxymethoxy and fluorine substituents enhance solubility and electronic tuning, while the tetramethyl-1,3,2-dioxaborolane moiety ensures high reactivity under mild conditions.

Application

This versatile boronate ester serves as a robust building block for Suzuki-Miyaura coupling reactions, enabling efficient C–C bond formation under mild conditions. The triisopropylsilyl-protected alkyne offers enhanced stability and compatibility with diverse functional groups, while the naphthalene core provides a rigid, electron-deficient scaffold suitable for advanced heterocyclic and pharmaceutical synthesis. Bench-stable and readily purified, it functions effectively in multi-step sequences requiring orthogonal reactivity.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   36.92
  • LogP   6.8303
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   7

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