Gamma-glutamylcysteine TFA

CAS No. 283159-88-6
Cat. No. CS-0101974
Purity≥95%
MDL No.MFCD00133357

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Description

Gamma-glutamylcysteine (TFA) is a key intermediate in glutathione biosynthesis, featuring a stable gamma-peptide bond and a trifluoroacetate counterion for enhanced solubility. This dipeptide derivative bears a reactive thiol group ideal for conjugation chemistry and maintains stability under standard bench conditions, enabling reliable use in biochemical assays and metabolic studies.

Application

Gamma-glutamylcysteine (TFA) serves as a key tripeptide precursor in glutathione biosynthesis, enabling efficient synthesis of reduced glutathione (GSH) and related thiol-containing compounds. The TFA salt enhances solubility and stability in aqueous systems, facilitating its use in enzymatic assays, redox biology studies, and peptide coupling workflows. Its amide-linked gamma-glutamyl moiety ensures compatibility with standard peptide protection strategies and supports reliable incorporation into larger bioactive scaffolds.

General Information

CAS No. 283159-88-6
Cat. No. CS-0101974
Purity ≥95%
MDL No. MFCD00133357
Storage polypeptide, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₅F₃N₂O₇S
Molecular Weight 364.30
Synonym(s) γ-Glu-Cys (TFA)
SMILES SC[C@@H](C(O)=O)NC(CC[C@H](N)C(O)=O)=O.OC(C(F)(F)F)=O

Computational Chemistry Data

TPSA 167.02
LogP -0.689
H_Acceptors 6
H_Donors 6
Rotatable_Bonds 7

Safety Information

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Signal Word : N/A	UN#: N/A
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Hazard Statements : N/A
Precautionary Statements : N/A

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Other Classifications

Bioactive Molecules Bioactive Small Molecules

Bioactive Molecules Natural Products

Key Words

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Gamma-glutamylcysteine TFA

CAS No. 283159-88-6

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