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1-(3-Hydroxypyridin-4-yl)ethanone

  • CAS No. 30152-05-7

  • Cat. No. CS-B0938
  • Molecule weight137.14
  • Purity≥98%
  • MDL No.MFCD18256467

*For research and further manufacturing use only, not for direct human use.

1-(3-Hydroxypyridin-4-yl)ethanone|CS-B0938

Structure of 30152-05-7

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General Information

  • CAS No. 30152-05-7
  • Cat. No. CS-B0938
  • Purity ≥98%
  • MDL No. MFCD18256467
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇NO₂
  • Molecular Weight 137.14
  • Synonym(s) Ethanone, 1-(3-hydroxy-4-pyridinyl)- (9CI)
  • SMILES CC(C1=C(O)C=NC=C1)=O

Description

1-(3-Hydroxypyridin-4-yl)ethanone features a pyridine ring bearing a hydroxyl group at the 3-position and a ketone at the 4-position, creating a polar, electron-deficient scaffold. This arrangement enables direct participation in hydrogen bonding and facilitates conjugation, enhancing solubility and reactivity in synthetic transformations. The molecule serves as a key intermediate for heterocyclic derivatives in medicinal chemistry and materials science applications.

Application

1-(3-Hydroxypyridin-4-yl)ethanone serves as a versatile building block in medicinal chemistry, enabling efficient access to pyridine-based pharmacophores. Its ketone functionality facilitates nucleophilic addition, reductive amination, and condensation reactions, while the adjacent hydroxyl group supports ortho-directed functionalization or protection strategies. The compound exhibits good bench stability and is compatible with standard purification techniques, making it well-suited for iterative synthesis workflows in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   0.9898
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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