6-Nitronicotinic acid

CAS No. 33225-73-9
Cat. No. CS-W003159
Purity≥96%
MDL No.MFCD04114183

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Description

6-Nitronicotinic acid features a nitro group positioned at the 6-position of the nicotinic acid scaffold, imparting strong electron-withdrawing character. This configuration enhances acidity and influences reactivity in electrophilic substitution and coupling processes. The molecule integrates readily into bioactive heterocycles and serves as a key intermediate in pharmaceutical synthesis under standard conditions.

Application

6-Nitronicotinic acid serves as a versatile building block in heterocyclic synthesis, enabling direct access to nitro-substituted pyridine scaffolds relevant to medicinal chemistry and agrochemical development. Its ortho-nitro functionality facilitates subsequent transformations such as reduction to amino derivatives or metal-catalyzed cross-couplings. The compound exhibits good bench stability and is readily purified by recrystallization, supporting its use in multi-step synthetic sequences requiring functional group compatibility and predictable reactivity.

General Information

CAS No. 33225-73-9
Cat. No. CS-W003159
Purity ≥96%
MDL No. MFCD04114183
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₄N₂O₄
Molecular Weight 168.11
Synonym(s) 6-nitropyridine-3-carboxylicaci; 6-Nitronicotinic acid
SMILES OC(=O)c1ccc(nc1)[N+](=O)[O-]

Computational Chemistry Data

TPSA 93.33
LogP 0.688
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 2

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Nitro compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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6-Nitronicotinic acid

CAS No. 33225-73-9

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