Cyclobutanecarboxylic acid

CAS No. 3721-95-7
Cat. No. CS-W011325
Purity≥98%
MDL No.MFCD00001323

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Structure of 3721-95-7

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Description

Cyclobutanecarboxylic acid features a strained four-membered ring that imparts unique reactivity and conformational rigidity. This structural motif enhances its utility in synthetic routes requiring defined stereochemistry or ring fusion. The carboxylic acid group enables direct functionalization or derivatization under standard conditions, making it valuable for building complex molecular architectures in medicinal chemistry and materials science.

Application

Cyclobutanecarboxylic acid serves as a valuable building block in medicinal chemistry and synthetic organic chemistry, offering a rigid, strained cyclobutane scaffold that enhances metabolic stability and bioavailability in drug candidates. Its carboxylic acid functionality enables direct derivatization into amides, esters, and acyl chlorides, facilitating downstream conjugation and incorporation into complex molecular architectures. The compound exhibits good bench stability and is compatible with standard functional group manipulations, making it well-suited for iterative synthesis workflows and API development.

General Information

CAS No. 3721-95-7
Cat. No. CS-W011325
Purity ≥98%
MDL No. MFCD00001323
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₈O₂
Molecular Weight 100.12
Synonym(s) cyclobutanecarboxylate; Cyclobutanecarboxylic acid
SMILES O=C(C1CCC1)O

Computational Chemistry Data

TPSA 37.3
LogP 0.8711
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 3265
Class : 8	Packing Group : Ⅲ
Hazard Statements : H227-H314
Precautionary Statements : P210-P260-P264-P280-P301+P330+P331-P304+P340-P363-P370+P378-P403-P405-P501

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Other Classifications

Building Blocks Skeleton Fatty ring compounds Cyclobutane compounds

Key Words

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Cyclobutanecarboxylic acid

CAS No. 3721-95-7

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