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CS-W001157 4
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2-(2-Fluoroethoxy)ethanol

  • CAS No. 373-22-8

  • Cat. No. CS-0199113
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-(2-Fluoroethoxy)ethanol|CS-0199113

Structure of 373-22-8

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General Information

  • CAS No. 373-22-8
  • Cat. No. CS-0199113
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₉FO₂
  • Molecular Weight 108.11
  • Synonym(s) 2-(2-fluoroethoxy)ethan-1-ol
  • SMILES C(COCCO)F

Description

2-(2-Fluoroethoxy)ethanol is a polar, bench-stable solvent featuring a fluorinated ether linkage that enhances solubility in both aqueous and organic phases. This compound integrates seamlessly into synthetic workflows requiring low-viscosity, moisture-tolerant media, offering improved compatibility with sensitive functional groups during reaction optimization.

Application

2-(2-Fluoroethoxy)ethanol serves as a versatile, bench-stable ether alcohol with enhanced solubility in polar aprotic media. It functions as a key building block in the synthesis of fluorinated bioactive molecules, enabling efficient incorporation of fluorinated alkyl chains into pharmaceutical scaffolds. Its compatibility with diverse functional groups and ease of purification make it well-suited for iterative synthetic workflows in medicinal chemistry and process development.

Synthesis

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      2-(2-Fluoroethoxy)ethanol|CS-0199113
      373-22-8

    References

    • THERACOS, INC.; SONG, Yanli Patent: WO2009/26537 A1, 2009 ; Location in patent: Page/Page column 76 ;
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      2-(2-Fluoroethoxy)ethanol|CS-0199113
      373-22-8

    References

    • Knunjanz Doklady Akademii Nauk SSSR, vol. 55, p. 223 Chem.Abstr., 1947 , p. 5855 Full Text Show Details Knunjanz; Kildischewa; Petrow Zhurnal Obshchei Khimii, vol. 19, p. 99 Chem.Abstr., 1949 , p. 6163
  • Route3
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      1262964-31-7
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    • In-stock
      2-(2-Fluoroethoxy)ethanol|CS-0199113
      373-22-8

    References

    • Van Oosten, Erik M.; Wilson, Alan A.; Mamo, David C.; Pollock, Bruce G.; Mulsant, Benoit H.; Houle, Sylvain; Vasdev, Neil Canadian Journal of Chemistry, 2010 , vol. 88, # 12 p. 1222 - 1232

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H227-H302-H315-H319-H335
Precautionary Statements : P210-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P370+P378-P403-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.46
  • LogP   -0.0352
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   4

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