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Structure of 403-42-9
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4'-Fluoroacetophenone features a fluorine atom at the para position of the phenyl ring, enhancing electron-withdrawal and directing electrophilic substitution. This bench-stable ketone integrates readily into synthetic routes requiring polarized carbonyl functionality and serves as a key intermediate in pharmaceutical and agrochemical development.
4'-Fluoroacetophenone serves as a versatile building block in synthetic organic chemistry, enabling efficient construction of fluorinated aromatic scaffolds. Its electrophilic ketone functionality facilitates nucleophilic additions, Grignard reactions, and Friedel-Crafts acylations with high regiocontrol. The ortho-fluorine substituent enhances metabolic stability and modulates electronic properties, making it valuable for medicinal chemistry applications. Bench-stable and readily purified by distillation or recrystallization, it functions reliably in multi-step syntheses.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: