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CS-W001157 4
Total: USD 88.00

2,4-Dimethylpyrimidin-5-ol

  • CAS No. 412003-95-3

  • Cat. No. CS-W005733
  • Molecule weight124.14
  • Purity≥97%
  • MDL No.MFCD18072447

*For research and further manufacturing use only, not for direct human use.

2,4-Dimethylpyrimidin-5-ol|CS-W005733

Structure of 412003-95-3

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General Information

  • CAS No. 412003-95-3
  • Cat. No. CS-W005733
  • Purity ≥97%
  • MDL No. MFCD18072447
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₈N₂O
  • Molecular Weight 124.14
  • Synonym(s) 5-Pyrimidinol, 2,4-dimethyl- (9CI)
  • SMILES OC1=CN=C(C)N=C1C

Description

2,4-Dimethylpyrimidin-5-ol features a pyrimidine core bearing methyl groups at positions 2 and 4, enhancing steric protection of the C5 hydroxyl. This bench-stable derivative exhibits improved solubility in organic solvents compared to unsubstituted analogs, enabling straightforward incorporation into synthetic sequences. The hydroxyl group serves as a versatile handle for derivatization, facilitating coupling reactions under mild conditions. Its electron-rich character supports efficient metal-catalyzed transformations, making it a valuable scaffold in medicinal chemistry and materials synthesis.

Application

2,4-Dimethylpyrimidin-5-ol serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyrimidine-based scaffolds. Its stability under standard reaction conditions and compatibility with common coupling protocols facilitate downstream functionalization. The molecule functions as a key intermediate in the synthesis of kinase inhibitors and other bioactive heterocycles, offering predictable reactivity and straightforward purification.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   46.01
  • LogP   0.79904
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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