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CS-W001157 4
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3,6-Difluoro-2-hydroxybenzaldehyde

  • CAS No. 502762-92-7

  • Cat. No. CS-W010903
  • Molecule weight158.10
  • Purity≥97%
  • MDL No.MFCD08275281

*For research and further manufacturing use only, not for direct human use.

3,6-Difluoro-2-hydroxybenzaldehyde|CS-W010903

Structure of 502762-92-7

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General Information

  • CAS No. 502762-92-7
  • Cat. No. CS-W010903
  • Purity ≥97%
  • MDL No. MFCD08275281
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄F₂O₂
  • Molecular Weight 158.10
  • Synonym(s) Benzaldehyde, 3,6-difluoro-2-hydroxy- (9CI)
  • SMILES O=CC1=C(F)C=CC(F)=C1O

Description

3,6-Difluoro-2-hydroxybenzaldehyde features a strategically positioned aldehyde group flanked by two fluorine atoms and a phenolic hydroxyl, enabling direct functionalization in synthetic sequences. This electron-deficient scaffold integrates readily into complex molecular architectures under mild conditions.

Application

3,6-Difluoro-2-hydroxybenzaldehyde serves as a versatile building block in medicinal chemistry, enabling direct incorporation of fluorinated aromatic motifs into bioactive scaffolds. Its ortho-hydroxyl and aldehyde functionalities support efficient cyclizations, metal-catalyzed couplings, and derivatization via condensation reactions. The molecule exhibits good bench stability and facilitates purification through crystallization or standard chromatographic methods, making it well-suited for iterative synthesis campaigns targeting fluorinated heterocycles and API intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   1.4829
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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