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Structure of 53005-44-0
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2-Methoxy-6-methylbenzonitrile features a benzene ring bearing a methoxy group at the ortho position relative to the nitrile, paired with a methyl substituent at the para position. This electron-rich aromatic scaffold enables selective coupling in cross-coupling reactions and serves as a key building block in pharmaceutical synthesis due to its stability and tunable reactivity.
2-Methoxy-6-methylbenzonitrile serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted benzimidazoles and other heterocyclic scaffolds. Its ortho-directed reactivity facilitates electrophilic substitution and transition-metal-catalyzed coupling reactions. The nitrile group offers robust functional group tolerance and provides a handle for downstream transformations, including amide formation and reduction to primary amines. Bench-stable and readily purified by recrystallization or column chromatography, it is well-suited for scale-up and multi-step synthesis workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: