5-Chloro-2,3-dimethylpyrazine

CAS No. 59489-32-6
Cat. No. CS-W022343
Purity≥97%
MDL No.MFCD13189517

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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5-Chloro-2,3-dimethylpyrazine|CS-W022343

Structure of 59489-32-6

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Description

5-Chloro-2,3-dimethylpyrazine is a heterocyclic compound featuring a pyrazine core with chlorine and methyl substituents at the 5- and 2,3-positions, respectively. This configuration imparts enhanced electron-deficient character and steric bulk, enabling its use in transition metal-catalyzed coupling reactions and as a building block in agrochemical and pharmaceutical synthesis. The molecule exhibits good thermal stability and handles well under standard bench conditions.

Application

5-Chloro-2,3-dimethylpyrazine serves as a versatile heterocyclic building block in medicinal chemistry and agrochemical synthesis. Its chlorine substituent enables palladium-catalyzed cross-coupling reactions, while the methyl groups enhance solubility and metabolic stability. The pyrazine core provides a rigid, electron-deficient scaffold suitable for targeted drug discovery. Bench-stable and readily purified by column chromatography, it functions effectively in standard synthetic workflows.

General Information

CAS No. 59489-32-6
Cat. No. CS-W022343
Purity ≥97%
MDL No. MFCD13189517
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₇ClN₂
Molecular Weight None
Synonym(s) 2-Chloro-5,6-dimethylpyrazine
SMILES CC1=C(C)N=C(Cl)C=N1

Computational Chemistry Data

TPSA 25.78
LogP 1.74684
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362+P364

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazine compounds

Key Words

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5-Chloro-2,3-dimethylpyrazine

CAS No. 59489-32-6

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