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CS-W001157 4
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2-Aminoacetamide

  • CAS No. 598-41-4

  • Cat. No. CS-0149938
  • Purity≥95%
  • MDL No.MFCD01859715

*For research and further manufacturing use only, not for direct human use.

2-Aminoacetamide|CS-0149938

Structure of 598-41-4

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General Information

  • CAS No. 598-41-4
  • Cat. No. CS-0149938
  • Purity ≥95%
  • MDL No. MFCD01859715
  • Storage -20°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂H₆N₂O
  • Molecular Weight 74.08
  • Synonym(s) Glycinamide
  • SMILES NC(CN)=O

Description

2-Aminoacetamide features a primary amine and amide group on adjacent carbon atoms, enabling direct integration into peptide-like architectures. This bifunctional scaffold supports conjugation strategies in chemical biology and serves as a key intermediate in synthesizing bioactive heterocycles under standard conditions.

Application

2-Aminoacetamide serves as a versatile building block in synthetic organic chemistry, enabling the construction of nitrogen-containing heterocycles and peptide-derived scaffolds. Its dual functionality—primary amine and amide group—supports orthogonal reactivity, facilitating coupling, cyclization, and derivatization under mild conditions. The compound exhibits good bench stability and is readily purified by recrystallization, making it well-suited for use in medicinal chemistry and process development workflows.

Synthesis

  • Route1

    References

    • Ganguly, Bishwajit; Kesharwani, Manoj K.; Basaric, Nikola; Suresh, Eringathodi; Biswas, Abul Kalam; Mlinaric-Majerski, Kata Journal of Molecular Graphics and Modelling, 2013 , vol. 46, p. 52 - 58
  • Route2
    • 2-Nitroacetamide|CS-0213050
      14011-21-3
    • ~%
    • In-stock
      2-Aminoacetamide|CS-0149938
      598-41-4

    References

    • US5055462 A1, ;
  • Route3

    References

    • Journal of the American Chemical Society, , vol. 74, p. 1580,1582

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   69.11
  • LogP   -1.5696
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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