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Structure of 622867-53-2
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tert-Butyl 6-(bromomethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate features a bromomethyl group at the 6-position of a dihydroisoquinoline scaffold, enabling facile functionalization in late-stage diversification. The tert-butyl ester offers enhanced stability and ease of handling under standard conditions. This building block integrates efficiently into synthetic sequences requiring selective alkylation or transition-metal-catalyzed coupling reactions.
tert-Butyl 6-(bromomethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate serves as a versatile synthetic intermediate for constructing isoquinoline-based scaffolds. The bromomethyl group enables efficient nucleophilic substitution reactions, facilitating the installation of diverse side chains under mild conditions. Its bench-stable tert-butyl carbamate protecting group offers excellent functional group tolerance and simplifies purification. This reagent is particularly valuable in medicinal chemistry campaigns requiring rapid diversification of dihydroisoquinoline cores.
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GHS Pictogram :
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GHS No : GHS05,GHS07
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Signal Word : Danger
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UN#: 3261
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Class : 8
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Packing Group : Ⅱ
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Hazard Statements : H302-H314
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Precautionary Statements : P260-P264-P270-P280-P301+P330+P331-P304+P340-P330-P363-P405-P501
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Lot numbers can be found on the outside label of a product: