H-Glu(OtBu)-OMe.HCl

CAS No. 6234-01-1
Cat. No. CS-W008383
Purity≥98%
MDL No.MFCD00153438

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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Structure of 6234-01-1

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Description

H-Glu(OtBu)-OMe.HCl features a protected glutamic acid side chain with tert-butyl ester and methyl ester functionalities, offering enhanced stability and ease of handling in peptide synthesis. This derivative enables straightforward incorporation into sequences where selective deprotection is required, facilitating efficient access to functionalized peptides under standard conditions.

Application

H-Glu(OtBu)-OMe·HCl serves as a key building block for the synthesis of biologically active peptides and peptidomimetics, offering a stable, bench-ready form of glutamic acid with orthogonal protection. The OtBu group ensures selective deprotection under mild acidic conditions, while the methyl ester enables efficient coupling in solid-phase and solution-phase syntheses. Its crystalline nature and compatibility with standard peptide coupling reagents facilitate reliable handling and purification.

General Information

CAS No. 6234-01-1
Cat. No. CS-W008383
Purity ≥98%
MDL No. MFCD00153438
Storage 4°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₂₀ClNO₄
Molecular Weight 253.72
Synonym(s) None
SMILES O=C([C@H](CCC(OC(C)(C)C)=O)N)OC.Cl

Computational Chemistry Data

TPSA 78.62
LogP 1.0304
H_Acceptors 5
H_Donors 1
Rotatable_Bonds 4

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Bioactive Molecules Peptides

Life Science Amino Acids and their Derivatives Glutamic acid and derivatives

Life Science Amino Acids and their Derivatives C-protected amino acid

Chemical Biology Pharmaceutical Development and Drug Discovery Research Peptide Chemistry Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Peptide Chemistry Amino Acid Derivatives

Chemical Biology Peptide Chemistry Amino Acid Derivatives

Biochemistry Biochemicals and Reagents Amino Acids C-ProtectedAmino Acids

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H-Glu(OtBu)-OMe.HCl

CAS No. 6234-01-1

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