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CS-W001157 4
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7-Hydroxy-2-methyl-4H-chromen-4-one

  • CAS No. 6320-42-9

  • Cat. No. CS-0153131
  • Molecule weight176.17
  • Purity≥95%
  • MDL No.MFCD00208225

*For research and further manufacturing use only, not for direct human use.

7-Hydroxy-2-methyl-4H-chromen-4-one|CS-0153131

Structure of 6320-42-9

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General Information

  • CAS No. 6320-42-9
  • Cat. No. CS-0153131
  • Purity ≥95%
  • MDL No. MFCD00208225
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₈O₃
  • Molecular Weight 176.17
  • Synonym(s) NSC 31894
  • SMILES CC1=CC(=O)C2=C(C=C(C=C2)O)O1

Description

An excitatory amino acid neurotransmitter. Selective agonist of the glutamate receptor that regulates Ca2+ channels. Important in long-term potentiation, ischemia, and epilepsy. NMDA receptors are involved in the "fine tuning" of synaptic connections in the developing brain. Chronic treatment with NMDA produces structural changes in synaptic morphology. Over-excitation of NMDA receptors causes neuronal degeneration and cell death.

Synthesis

  • Route1
    • null|null
      83526-81-2
    • ~%
    • 7-Hydroxy-2-methyl-4H-chromen-4-one|CS-0153131
      6320-42-9

    References

    • Ungwitayatorn, Jiraporn; Wiwat, Chanpen; Samee, Weerasak; Nunthanavanit, Patcharawee; Phosrithong, Narumol Journal of Molecular Structure, 2011 , vol. 1001, # 1-3 p. 152 - 161
  • Route2
    • null|null
      34086-77-6
    • ~61%
    • 7-Hydroxy-2-methyl-4H-chromen-4-one|CS-0153131
      6320-42-9

    References

    • Ahluwalia, Vinod Kumar; Jain, Anjula; Gupta, Ranjna Bulletin of the Chemical Society of Japan, 1982 , vol. 55, # 8 p. 2649 - 2652
  • Route3

    References

    • Yu, Donglei; Chen, Chin-Ho; Brossi, Arnold; Lee, Kuo-Hsiung Journal of Medicinal Chemistry, 2004 , vol. 47, # 16 p. 4072 - 4082

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319
Precautionary Statements : P264-P270-P280-P302+P352-P330-P362+P364-P501

Quality Control

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Computational Chemistry Data

  • TPSA   50.44
  • LogP   1.80702
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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