Lot numbers can be found on the outside label of a product:
5-Chloro-1H-pyrazolo[4,3-d]pyrimidine
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CAS No. 633328-98-0
- Cat. No. CS-0045848
- Purity≥95%
- MDL No.MFCD18251003
*For research and further manufacturing use only, not for direct human use.
![5-Chloro-1H-pyrazolo[4,3-d]pyrimidine|CS-0045848](https://file.chemscene.com/productPIC/CS-0045848.gif)
Structure of 633328-98-0
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General Information
- CAS No. 633328-98-0
- Cat. No. CS-0045848
- Purity ≥95%
- MDL No. MFCD18251003
- Storage -20°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₅H₃ClN₄
- Molecular Weight 154.56
- Synonym(s) 5-Chloropyrazolo[4,3-d]pyrimidine
- SMILES ClC1=NC=C(NN=C2)C2=N1
Description
5-Chloro-1H-pyrazolo[4,3-d]pyrimidine is a heterocyclic scaffold featuring a chlorine atom at the 5-position, enabling direct functionalization in medicinal chemistry. This electron-deficient core integrates readily into kinase inhibitors and antiviral agents, offering high reactivity under standard coupling conditions. The pyrazolopyrimidine framework provides structural rigidity and enhanced binding affinity in target-directed synthesis.
Application
5-Chloro-1H-pyrazolo[4,3-d]pyrimidine serves as a versatile heterocyclic building block for medicinal chemistry and agrochemical synthesis. Its chloro substituent enables palladium-catalyzed cross-coupling reactions, facilitating the construction of diverse biaryl and aryl-substituted scaffolds. The core pyrazolopyrimidine framework exhibits excellent bench stability and compatibility with common functional groups, enabling efficient incorporation into complex molecular architectures through standard synthetic protocols.
Synthesis
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Route1
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![1-{5-chloro-1h-pyrazolo[4,3-d]pyrimidin-1-yl}ethan-1-one|CS-0244716](https://file.chemscene.com/productPIC/CS-0244716.gif)
633328-97-9 - ~45%
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In-stock
633328-98-0
References
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Heald, Robert; Price, Stephen; Safina, Brian; Savy, Pascal Pierre Alexandre; Seward, Eileen Mary; Sutherlin, Daniel P.; Waszkowycz, Bohdan Patent: US2012/202785 A1, 2012 ; Location in patent: Page/Page column 263 ;
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Route2
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633328-96-8 - ~%
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In-stock
633328-98-0
References
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Heald, Robert; Price, Stephen; Safina, Brian; Savy, Pascal Pierre Alexandre; Seward, Eileen Mary; Sutherlin, Daniel P.; Waszkowycz, Bohdan Patent: US2012/202785 A1, 2012 ;
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Route3
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In-stock
20090-69-1 - ~%
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In-stock
633328-98-0
References
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Heald, Robert; Price, Stephen; Safina, Brian; Savy, Pascal Pierre Alexandre; Seward, Eileen Mary; Sutherlin, Daniel P.; Waszkowycz, Bohdan Patent: US2012/202785 A1, 2012 ;
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 54.46
- LogP 1.0063
- H_Acceptors 3
- H_Donors 1
- Rotatable_Bonds 0
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Key Words
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