(R)-Tetrahydrofuran-3-carboxylic acid

CAS No. 66838-42-4
Cat. No. CS-W006196
Purity≥95%
MDL No.MFCD07369940

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(R)-Tetrahydrofuran-3-carboxylic acid|CS-W006196

Structure of 66838-42-4

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Description

(R)-Tetrahydrofuran-3-carboxylic acid is a chiral building block featuring a stereodefined tetrahydrofuran ring fused to a carboxylic acid moiety. This configuration enables selective incorporation into bioactive molecules, particularly in medicinal chemistry and asymmetric synthesis. The compound exhibits enhanced solubility in polar solvents and stability under standard bench conditions, facilitating its use in multi-step synthetic sequences.

Application

(R)-Tetrahydrofuran-3-carboxylic acid serves as a chiral building block for medicinal chemistry and catalytic synthesis, offering high enantiomeric purity and stability under standard reaction conditions. Its carboxylic acid functionality enables direct derivatization into amides, esters, or acyl chlorides, while the tetrahydrofuran ring provides structural rigidity and favorable solubility. The compound functions reliably in asymmetric synthesis, peptide coupling, and heterocycle formation workflows.

General Information

CAS No. 66838-42-4
Cat. No. CS-W006196
Purity ≥95%
MDL No. MFCD07369940
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₈O₃
Molecular Weight None
Synonym(s) (R)-Tetrahydro-3-furoic acid
SMILES O=C([C@H]1COCC1)O

Computational Chemistry Data

TPSA 46.53
LogP 0.1075
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H319
Precautionary Statements : P264-P280-P305+P351+P338-P337+P313

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Other Classifications

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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(R)-Tetrahydrofuran-3-carboxylic acid

CAS No. 66838-42-4

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