2-Fluoro-5-nitrobenzenesulfonyl chloride

CAS No. 713-21-3
Cat. No. CS-0157161
Purity≥95%
MDL No.MFCD08443561

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2-Fluoro-5-nitrobenzenesulfonyl chloride|CS-0157161

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Description

2-Fluoro-5-nitrobenzenesulfonyl chloride features a sulfonyl chloride group flanked by electron-withdrawing fluorine and nitro substituents, enhancing reactivity in nucleophilic aromatic substitution. This bench-stable reagent facilitates efficient sulfonamide formation under mild conditions, offering high selectivity for functionalization in complex molecular architectures.

Application

2-Fluoro-5-nitrobenzenesulfonyl chloride serves as a versatile sulfonylating agent for the selective introduction of sulfonamide groups under mild conditions. Its electron-withdrawing fluorine and nitro substituents enhance reactivity while maintaining bench stability, enabling efficient functionalization of amines, including sensitive heterocyclic and peptide substrates. The compound facilitates clean, high-yielding transformations with minimal side reactions, supporting scalable synthesis workflows in medicinal chemistry and agrochemical development.

General Information

CAS No. 713-21-3
Cat. No. CS-0157161
Purity ≥95%
MDL No. MFCD08443561
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₃ClFNO₄S
Molecular Weight 239.61
Synonym(s) 2-Fluoro-5-nitrobenzenesulphonylchloride
SMILES C1=CC(=C(C=C1[N+](=O)[O-])S(=O)(=O)Cl)F

Computational Chemistry Data

TPSA 77.28
LogP 1.6614
H_Acceptors 4
H_Donors 0
Rotatable_Bonds 2

Safety Information

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GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 3265
Class : 8	Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P280-P301+P330+P331-P304+P340

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Other Classifications

Building Blocks Functional Group Sulfonyl Chloride

Building Blocks Functional Group Nitro compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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2-Fluoro-5-nitrobenzenesulfonyl chloride

CAS No. 713-21-3

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