7-Chloro-L-tryptophan

CAS No. 73945-46-7
Cat. No. CS-D0040
Molecule weight238.67
Purity≥97%
MDL No.MFCD09264322

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 73945-46-7
Cat. No. CS-D0040
Purity ≥97%
MDL No. MFCD09264322
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₁₁ClN₂O₂
Molecular Weight 238.67
Synonym(s) 7-CHLORO-L-TRYPTOPHAN USP/EP/BP
SMILES N[C@@H](CC1=CNC2=C(Cl)C=CC=C12)C(O)=O

Description

7-Chloro-L-tryptophan integrates a chlorinated indole moiety into the L-tryptophan scaffold, enabling site-specific incorporation into peptides for probing protein function. This analog enhances structural diversity in chemical biology studies and supports metabolic labeling strategies where native tryptophan is replaced.

Application

7-Chloro-L-tryptophan serves as a valuable building block for the synthesis of biologically active indole derivatives and serotonin analogs. Its chlorine substituent enhances metabolic stability and modulates receptor affinity in CNS-targeted compounds. The molecule exhibits excellent bench stability, facilitates straightforward peptide coupling reactions, and is compatible with standard protecting group strategies in solid-phase and solution-phase syntheses.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 79.11
LogP 1.7757
H_Acceptors 2
H_Donors 3
Rotatable_Bonds 3

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7-Chloro-L-tryptophan

CAS No. 73945-46-7

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