5,7-dichloro-3-ethylpyrazolo[1,5-a]pyrimidine

CAS No. 779353-64-9
Cat. No. CS-B0797
Purity≥95%
MDL No.MFCD08448153

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5,7-dichloro-3-ethylpyrazolo[1,5-a]pyrimidine|CS-B0797

Structure of 779353-64-9

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Description

5,7-Dichloro-3-ethylpyrazolo[1,5-a]pyrimidine features a rigid heteroaromatic core with strategically positioned electron-withdrawing chloro groups and a lipophilic ethyl substituent. This combination enhances its utility in constructing bioactive scaffolds, particularly in kinase inhibitor development and medicinal chemistry campaigns requiring moderate metabolic stability and controlled reactivity under standard conditions.

Application

5,7-Dichloro-3-ethylpyrazolo[1,5-a]pyrimidine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient construction of kinase inhibitor scaffolds. Its electron-deficient pyrazolopyrimidine core facilitates nucleophilic substitution and palladium-catalyzed coupling reactions. The dichloro substituents provide orthogonal reactivity for selective functionalization, while the ethyl group enhances solubility and modulates electronic properties. Bench-stable and amenable to standard purification methods, it functions reliably in multi-step syntheses targeting bioactive molecules.

General Information

CAS No. 779353-64-9
Cat. No. CS-B0797
Purity ≥95%
MDL No. MFCD08448153
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₇Cl₂N₃
Molecular Weight 216.07
Synonym(s) Pyrazolo[1,5-a]pyrimidine, 5,7-dichloro-3-ethyl- (9CI)
SMILES CCC1=C2N=C(Cl)C=C(Cl)N2N=C1

Computational Chemistry Data

TPSA 30.19
LogP 2.5985
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazole compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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5,7-dichloro-3-ethylpyrazolo[1,5-a]pyrimidine

CAS No. 779353-64-9

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