Fmoc-His(Boc)-OH

CAS No. 81379-52-4
Cat. No. CS-0067108
Molecule weightNone
Purity≥95%
MDL No.MFCD00151928

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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General Information

CAS No. 81379-52-4
Cat. No. CS-0067108
Purity ≥95%
MDL No. MFCD00151928
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₆H₂₇N₃O₆
Molecular Weight None
Synonym(s) 1-[(1,1-Dimethylethoxy)carbonyl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-histidine
SMILES O=C(O)[C@H](CC1=CN(C(OC(C)(C)C)=O)C=N1)NC(OCC2C3=C(C4=C2C=CC=C4)C=CC=C3)=O

Description

Fmoc-His(Boc)-OH is a protected histidine derivative designed for solid-phase peptide synthesis. The Fmoc group enables orthogonal protection, while the Boc moiety stabilizes the imidazole side chain. This combination ensures high fidelity during coupling steps and simplifies deprotection workflows. The molecule exhibits excellent solubility in common organic solvents and maintains stability under standard bench conditions.

Application

Fmoc-His(Boc)-OH serves as a key building block in solid-phase peptide synthesis, offering orthogonal protection of both the Nα-amino and imidazole side-chain functionalities. The Fmoc group enables base-labile removal under mild conditions, while the Boc-protected imidazole ensures stability during coupling steps. This derivative facilitates efficient incorporation of histidine residues with high fidelity, supports clean deprotection sequences, and enhances purification ease due to improved solubility and reduced aggregation.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

TPSA 119.75
LogP 4.2007
H_Acceptors 7
H_Donors 2
Rotatable_Bonds 6

Other Classifications

Bioactive Molecules Peptides

Building Blocks Functional Group Fmoc

Life Science Amino Acids and their Derivatives Histidine and derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Peptide Chemistry Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Peptide Chemistry Amino Acid Derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Amino Acid Derivatives

Biochemistry Biochemicals and Reagents Amino Acids N-Protected Amino Acids

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Fmoc-His(Boc)-OH

CAS No. 81379-52-4

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