N-Boc-4-oxo-L-proline

CAS No. 84348-37-8
Cat. No. CS-M1682
Purity≥97%
MDL No.MFCD01860669

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Description

N-Boc-4-oxo-L-proline features a protected amine and a ketone-functionalized pyrrolidine ring, enabling direct incorporation into peptide syntheses. This bench-stable derivative supports efficient access to oxoprolines in bioactive molecule development.

Application

N-Boc-4-oxo-L-proline serves as a versatile building block in peptide synthesis and heterocyclic chemistry, enabling efficient access to pyrrolidine-based scaffolds. The Boc group provides excellent stability and ease of removal under mild acidic conditions, while the 4-oxo functionality supports diverse transformations including reductive amination and nucleophilic addition. Its compatibility with standard coupling protocols and predictable reactivity make it a reliable choice for constructing complex bioactive molecules.

General Information

CAS No. 84348-37-8
Cat. No. CS-M1682
Purity ≥97%
MDL No. MFCD01860669
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₅NO₅
Molecular Weight 229.23
Synonym(s) Boc-4-oxo-Pro-OH
SMILES CC(C)(OC(N1CC(C[C@H]1C(O)=O)=O)=O)C

Computational Chemistry Data

TPSA 83.91
LogP 0.6495
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Amino Acids and their Derivatives Proline and derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Peptide Chemistry Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Peptide Chemistry Unnatural Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Peptide Chemistry Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Peptide Chemistry Unnatural Amino Acid Derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Amino Acid Derivatives

Biochemistry Biochemicals and Reagents Amino Acids N-Protected Amino Acids

Key Words

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N-Boc-4-oxo-L-proline

CAS No. 84348-37-8

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