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CS-W001157 4
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O-Desmethyl gefitinib

  • CAS No. 847949-49-9

  • Cat. No. CS-0018043
  • Molecule weight432.88
  • Purity≥98%
  • MDL No.MFCD09952182

*For research and further manufacturing use only, not for direct human use.

O-Desmethyl gefitinib|CS-0018043

Structure of 847949-49-9

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General Information

  • CAS No. 847949-49-9
  • Cat. No. CS-0018043
  • Purity ≥98%
  • MDL No. MFCD09952182
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₁H₂₂ClFN₄O₃
  • Molecular Weight 432.88
  • Synonym(s) None
  • SMILES OC1=CC2=NC=NC(NC3=CC=C(F)C(Cl)=C3)=C2C=C1OCCCN4CCOCC4

Description

Inhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle in a dose- and time-dependent manner and increases the Ca2+ permeability of SR vesicles. Useful for specific inactivation of nucleases during isolation of undegraded polynucleotides. Also inhibits platelet-activating factor acetyl hydrolase. Has been used as a probe for the topography of 5.8S rRNA in yeast ribosomes.

Synthesis

  • Route1

    References

    • Tetrahedron Letters, , vol. 46, # 43 p. 7381 - 7384
  • Route2

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 15 p. 4102 - 4106
  • Route3
    • 4-(3-Chloropropyl)morpholine Pramoxine Impurity|CS-0229750
      7357-67-7
    • ~%
    • In-stock
      O-Desmethyl gefitinib|CS-0018043
      847949-49-9

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 15 p. 4102 - 4106

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   79.74
  • LogP   3.9726
  • H_Acceptors   7
  • H_Donors   2
  • Rotatable_Bonds   7

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