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CS-W001157 4
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1-((4-Fluorophenyl)carbamoyl)cyclopropane-1-carboxylic acid Cabozantinib impurity

  • CAS No. 849217-48-7

  • Cat. No. CS-1370195
  • Molecule weight223.20
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-((4-Fluorophenyl)carbamoyl)cyclopropane-1-carboxylic acid Cabozantinib impurity|CS-1370195

Structure of 849217-48-7

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General Information

  • CAS No. 849217-48-7
  • Cat. No. CS-1370195
  • Purity ≥98%
  • MDL No. None
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₀FNO₃
  • Molecular Weight 223.20
  • Synonym(s) None
  • SMILES O=C(C1(CC1)C(NC2=CC=C(C=C2)F)=O)O

Synthesis

  • Route1
    • Cyclopropane-1,1-dicarboxylic acid  Cabozantinib Impurity|CS-0167007
      598-10-7
    • null|null
      371-40-4
    • ~75%
    • In-stock
      1-((4-Fluorophenyl)carbamoyl)cyclopropane-1-carboxylic acid Cabozantinib impurity|CS-1370195
      849217-48-7

    References

    • EXELIXIS, INC.; AFTAB, Dana, T; SCHIMMOLLER, Frauke Patent: WO2013/70890 A1, 2013 ; Location in patent: Paragraph 00114-00116 ;
  • Route2
    • Methyl 1-((4-fluorophenyl)carbamoyl)cyclopropanecarboxylate|CS-0161985
      1345847-71-3
    • ~91%
    • In-stock
      1-((4-Fluorophenyl)carbamoyl)cyclopropane-1-carboxylic acid Cabozantinib impurity|CS-1370195
      849217-48-7

    References

    • DECIPHERA PHARMACEUTICALS, LLC; FLYNN, Daniel L.; KAUFMAN, Michael D. Patent: WO2011/137342 A1, 2011 ; Location in patent: Page/Page column 34 ; WO 2011/137342 A1
  • Route3
    • Ethyl 1-((4-fluorophenyl)carbamoyl)cyclopropane-1-carboxylate|CS-1218321
      1245931-90-1
    • ~99%
    • In-stock
      1-((4-Fluorophenyl)carbamoyl)cyclopropane-1-carboxylic acid Cabozantinib impurity|CS-1370195
      849217-48-7

    References

    • Xi, Ning Patent: US2010/239576 A1, 2010 ; US 20100239576 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362+P364

Quality Control

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Computational Chemistry Data

  • TPSA   N/A
  • LogP   N/A
  • H_Acceptors   N/A
  • H_Donors   N/A
  • Rotatable_Bonds   N/A

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