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(6-Chloropyridin-3-yl)(cyclopropyl)methanone

  • CAS No. 872088-06-7

  • Cat. No. CS-0155402
  • Molecule weight181.62
  • Purity≥98%
  • MDL No.MFCD08437184

*For research and further manufacturing use only, not for direct human use.

(6-Chloropyridin-3-yl)(cyclopropyl)methanone|CS-0155402

Structure of 872088-06-7

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General Information

  • CAS No. 872088-06-7
  • Cat. No. CS-0155402
  • Purity ≥98%
  • MDL No. MFCD08437184
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈ClNO
  • Molecular Weight 181.62
  • Synonym(s) (6-CHLOROPYRIDIN-3-YL)-CYCLOPROPYL-METHANONE
  • SMILES C1CC1C(=O)C2=CN=C(C=C2)Cl

Description

(6-Chloropyridin-3-yl)(cyclopropyl)methanone is a bench-stable, moisture-tolerant ketone featuring a chlorinated pyridine ring paired with a cyclopropyl substituent. This structural combination delivers enhanced electronic and steric control, enabling efficient coupling in late-stage functionalization and heterocyclic synthesis. The molecule integrates readily into complex scaffolds under standard conditions.

Application

(6-Chloropyridin-3-yl)(cyclopropyl)methanone serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds via nucleophilic substitution and cross-coupling reactions. The chloropyridine moiety provides a reliable handle for further functionalization, while the cyclopropyl ketone group offers steric and electronic modulation. Bench-stable and compatible with standard reaction conditions, it facilitates rapid diversification in target-oriented synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H311-H331
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P405-P501

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   2.3277
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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