4-(1H-Pyrazol-4-yl)-7-[[2-(trimethylsilyl)ethoxy]methyl]-7H-pyrrolo[2,3-d]pyrimidine

CAS No. 941685-27-4
Cat. No. CS-M2189
Purity≥98%
MDL No.MFCD11857754

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4-(1H-Pyrazol-4-yl)-7-[[2-(trimethylsilyl)ethoxy]methyl]-7H-pyrrolo[2,3-d]pyrimidine|CS-M2189

Structure of 941685-27-4

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Description

This pyrrolopyrimidine derivative features a pyrazole substituent and a trimethylsilyl-protected ether side chain, enabling stable storage and controlled deprotection. The silyl group facilitates orthogonal functionalization, while the electron-rich heterocyclic core supports efficient coupling in synthetic applications.

Application

4-(1H-Pyrazol-4-yl)-7-[[2-(trimethylsilyl)ethoxy]methyl]-7H-pyrrolo[2,3-d]pyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient access to purine-derived scaffolds. Its pyrazole moiety provides a robust hydrogen-bonding interface, while the trimethylsilyl-protected ether facilitates orthogonal deprotection and stability during multistep synthesis. The compound exhibits excellent bench stability and compatibility with standard coupling reactions, making it well-suited for modular assembly of kinase inhibitors and nucleoside analogs.

General Information

CAS No. 941685-27-4
Cat. No. CS-M2189
Purity ≥98%
MDL No. MFCD11857754
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₅H₂₁N₅OSi
Molecular Weight None
Synonym(s) None
SMILES C[Si](C)(C)CCOCN(C=C1)C2=C1C(C3=CNN=C3)=NC=N2

Computational Chemistry Data

TPSA 68.62
LogP 3.1337
H_Acceptors 5
H_Donors 1
Rotatable_Bonds 6

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P301+P310-P302+P352-P304+P341-P312-P330-P363-P501

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Other Classifications

Bioactive Molecules Dye and Bio-assay Reagents

Building Blocks Functional Group Ether

Building Blocks Functional Group Organosilicon compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyrrole compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazole compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Material Science Organic-Inorganic Hybrid Materials A silane coupling agent

Key Words

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4-(1H-Pyrazol-4-yl)-7-[[2-(trimethylsilyl)ethoxy]methyl]-7H-pyrrolo[2,3-d]pyrimidine

CAS No. 941685-27-4

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