Ruxolitinib impurity-1

CAS No. 952518-97-7
Cat. No. CS-0051064
Purity≥97%
MDL No.MFCD20683197

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Structure of 952518-97-7

Size

Price

Quantity

* Please select Quantity before adding items.

Description

Ruxolitinib impurity-1 is a structurally defined byproduct arising during the synthesis of ruxolitinib, characterized by a substituted pyrazole core with an unreacted amine functionality. This impurity features enhanced polarity compared to the parent compound and is prone to oxidation under ambient conditions. It presents challenges in purification due to its similar chromatographic behavior to the active pharmaceutical ingredient.

Application

Ruxolitinib impurity-1 serves as a well-characterized structural analog in the synthesis of JAK inhibitors, enabling reliable monitoring of process-related byproducts. Its defined structure facilitates consistent purification and analytical assessment in quality control workflows. This impurity functions as a critical reference standard for validating synthetic routes and ensuring batch-to-batch consistency in pharmaceutical development.

General Information

CAS No. 952518-97-7
Cat. No. CS-0051064
Purity ≥97%
MDL No. MFCD20683197
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₇N₅
Molecular Weight 185.19
Synonym(s) None
SMILES N1C=C(C=N1)C1=NC=NC2=C1C=CN2

Computational Chemistry Data

TPSA 70.25
LogP 1.348
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazole compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

Ruxolitinib impurity-1 sigmaRuxolitinib impurity-1 manufacturerRuxolitinib impurity-1 priceRuxolitinib impurity-1 structureRuxolitinib impurity-1 SDSbuy Ruxolitinib impurity-1Ruxolitinib impurity-1 supplierRuxolitinib impurity-1 usesRuxolitinib impurity-1 molecular weightprice of Ruxolitinib impurity-1Ruxolitinib impurity-1 chemical name formula of Ruxolitinib impurity-1

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

Ruxolitinib impurity-1

CAS No. 952518-97-7

Recommended Products