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CS-W001157 4
Total: USD 88.00

6,7-Dichloro-1,2,3,4-tetrahydroisoquinoline hydrochloride

  • CAS No. 73075-49-7

  • Cat. No. CS-0096138
  • Molecule weight238.54
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6,7-Dichloro-1,2,3,4-tetrahydroisoquinoline hydrochloride|CS-0096138

Structure of 73075-49-7

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General Information

  • CAS No. 73075-49-7
  • Cat. No. CS-0096138
  • Purity ≥97%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₀Cl₃N
  • Molecular Weight 238.54
  • Synonym(s) 6,7-Dichloro-1,2,3,4-tetrahydro-isoquinoline hydrochloride
  • SMILES ClC1=CC2=C(C=C1Cl)CCNC2.[H]Cl

Description

6,7-Dichloro-1,2,3,4-tetrahydroisoquinoline hydrochloride is a bench-stable, moisture-tolerant heterocyclic amine featuring two chlorine substituents at the 6 and 7 positions. This electron-deficient scaffold integrates readily into medicinal chemistry libraries, offering enhanced metabolic stability and improved membrane permeability for CNS-targeted drug discovery.

Application

6,7-Dichloro-1,2,3,4-tetrahydroisoquinoline hydrochloride serves as a valuable building block in medicinal chemistry, enabling efficient access to substituted isoquinoline scaffolds. The dichloro substitution pattern enhances metabolic stability and modulates electronic properties, while the hydrochloride salt ensures excellent bench stability and ease of handling. It functions as a versatile intermediate in coupling reactions and heterocycle functionalization, supporting robust synthetic workflows for drug discovery and process development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   3.0609
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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