2,2,2-Trifluoro-1-(4-hydroxyphenyl)ethanone

CAS No. 1823-63-8
Cat. No. CS-0130348
Purity≥97%
MDL No.None

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FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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2,2,2-Trifluoro-1-(4-hydroxyphenyl)ethanone|CS-0130348

Structure of 1823-63-8

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Description

2,2,2-Trifluoro-1-(4-hydroxyphenyl)ethanone features a trifluoromethyl group flanking a phenolic hydroxyl, delivering enhanced electron-withdrawing character and improved metabolic stability. This scaffold integrates readily into bioactive molecules requiring polar, lipophilic domains with controlled solubility and resistance to oxidative degradation under standard conditions.

Application

2,2,2-Trifluoro-1-(4-hydroxyphenyl)ethanone serves as a valuable building block in medicinal chemistry, enabling the synthesis of fluorinated aryl ketones via standard condensation and coupling reactions. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the phenolic hydroxyl facilitates further derivatization. Its bench-stable nature and compatibility with common protecting group strategies streamline downstream functionalization in API development workflows.

General Information

CAS No. 1823-63-8
Cat. No. CS-0130348
Purity ≥97%
MDL No. None
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₅F₃O₂
Molecular Weight 190.12
Synonym(s) 4'-Hydroxy-2,2,2-trifluoroacetophenone
SMILES OC1=CC=C(C=C1)C(C(F)(F)F)=O

Computational Chemistry Data

TPSA 37.3
LogP 2.1372
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Ketone

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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2,2,2-Trifluoro-1-(4-hydroxyphenyl)ethanone

CAS No. 1823-63-8

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