IRAK4
Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) belongs to a family of four kinases (IRAK1, IRAK2, IRAK-M and IRAK4). IRAK4 is a serine/ threonine kinase which plays a crucial role in regulating Toll-Like receptors (TLR) and interleukin-1 receptors (IL-1R) signal. IRAK4 is recruited by the adaptor molecule Myeloid Differentiation primary response gene 88 (MyD88) after TLR activation, which results in activation of nuclear factor kappa B (NF-κB) and type I interferon (IFN) pathways. IRAK4 overactivation is linked with several autoimmune diseases, such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). In addition, IRAK4 has been shown to be associated with lymphocytic leukemia, lymphoma, and fibrotic disorders. Therefore, inhibitors of IRAK4 may be useful in the treatment of inflammatory disorders and cancers.
Technical Resources
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Catalytic asymmetric Friedel–Crafts alkylation of unprotected indoles with nitroalkenes using a novel chiralChiral chloro-indeno pybox has served as a new ligand for the Yb(OTf)3-catalyzed asymmetric Friedel–Crafts alkylation reaction of indoles with nitroalkenes. The tunable nature of pybox ligands
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2Catalytic asymmetric Friedel–Crafts alkylation of unprotected indoles with nitroalkenes using a novel chiral
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3Catalytic asymmetric Friedel–Crafts alkylation of unprotected indoles with nitroalkenes using a novel chiral
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4Catalytic asymmetric Friedel–Crafts alkylation of unprotected indoles with nitroalkenes using a novel chiral
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5Catalytic asymmetric Friedel–Crafts alkylation of unprotected indoles with nitroalkenes using a novel chiral
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In-stockPurity: ≥98%
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In-stockPurity: ≥98%
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In-stockPurity: ≥98%
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In-stockPurity: ≥98%
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In-stockPurity: ≥98%
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Cat. No. : CS-0996502CAS No. : 1001433-41-5* This product is not sold in the region.
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In-stockPurity: ≥95%
Cat. No. : CS-1007994 -
In-stockPurity: ≥98%
Cat. No. : CS-1007997CAS No. : 3027840-10-1* This product is not sold in the region.
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In-stockPurity: ≥98%
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In-stockPurity: ≥98%
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In-stockPurity: ≥98%
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