Proteolysis Targeting Chimera Research Reagents
PROTACs consist of a small molecule ligand that binds to a target protein and brings it into proximity with an E3 ubiquitin ligase, resulting in its ubiquitination and subsequent degradation by the proteasome machinery. These research reagents are used to study protein function, discover new drug targets , and develop novel therapeutic strategies for diseases such as cancer and neurodegenerative disorders.
Technical Resources
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Catalytic asymmetric Friedel–Crafts alkylation of unprotected indoles with nitroalkenes using a novel chiralChiral chloro-indeno pybox has served as a new ligand for the Yb(OTf)3-catalyzed asymmetric Friedel–Crafts alkylation reaction of indoles with nitroalkenes. The tunable nature of pybox ligands
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2Catalytic asymmetric Friedel–Crafts alkylation of unprotected indoles with nitroalkenes using a novel chiral
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3Catalytic asymmetric Friedel–Crafts alkylation of unprotected indoles with nitroalkenes using a novel chiral
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4Catalytic asymmetric Friedel–Crafts alkylation of unprotected indoles with nitroalkenes using a novel chiral
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5Catalytic asymmetric Friedel–Crafts alkylation of unprotected indoles with nitroalkenes using a novel chiral