Thiolorolines are macrocyclic compounds derived from calixarenes in which sulfur atoms replace some of the oxygen atoms in the ring. They are used as supramolecular host materials due to their ability to form stable complexes with guest molecules through ion-dipole interactions and hydrogen bonding. The sulfur atoms in the thiocalixarenes ring provide additional binding sites and regulatory options for host-guest interactions. Applications include ion separation, catalysis, and the development of new materials for sensing and recognition. In supramolecular chemistry, thiocalixarenes are used to create functional supramolecular structures and explore novel host-guest systems.