Fragment Library
| Cat. No. : CS-L032 |
|---|
| （23,342） |
| Library Contents: |
| Fragment-based drug discovery (FBDD) is well suited for discovering both drug leads and chemical probes of protein function; it can cover broad swaths of chemical space and allows the use of creative chemistry. Fragment-based drug discovery is well-established in industry and has resulted in a variety of drugs entering clinical trials, with two, vemurafenib and venetoclax, already approved. FBDD also has key attractions for academia. Notably, it is able to tackle difficult or novel targets for which no chemical matter may be found in existing HTS collections. ChemScene designs a unique collection of 23,342 fragment compounds, all of which obey a heuristic rule called the “Rule of Three (RO3) ”, in which molecular weight ≤300 Da, the number of hydrogen bond donors (H-donors) ≤3, the number of hydrogen bond acceptors (H-acceptors) is ≤3 and cLogP is ≤3. This library is an important source of lead-like drugs. |
| Size (Pre-dissolved DMSO or Solid) | Stock | Price |
|---|---|---|
| In-stock | Get quote |
Products are for research use only. Not for human use. We do not sell to patients.
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Data Sheet
Description & Advantages
Composition
| Formulation: | A collection of 23,342 fragment compounds supplied as pre-dissolved Solutions or Solid |
|---|---|
| Container: | 96- or 384-well Plate with Peelable Foil Seal |
| Storage: | -80°C |
| Shipping: | Blue ice or dry ice |
• A unique collection of 23,342 fragment compounds for traditional lead identification via high-throughput screening (HTS).
• The compounds follow the Rule of Three.
• A useful tool for the fragment-based approach to drug discovery (FBDD).
• More detailed compound information with structure, Molecular Weight, cLogP, H-donor and H-acceptor number.
• NMR and HPLC validated ensure high purity.
• All compounds are in stock and continuously updated.
| Parameter | Range | Average Value |
|---|---|---|
| Molecular Weight | ≤300 | 181.43 |
| cLogP | ≤3.0 | 1.6105 |
| H-donors | ≤3.0 | 2.07 |
| H-acceptors | ≤3.0 | 0.78 |
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