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Structure of 100-68-5
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A cell-permeable thiophenecarboxamide-ureido compound that acts as a potent, ATP-binding pocket-targeting inhibitor of IKK-2 (IC50 = 25 nM), while affecting IKK-1 and JNK1 only at much higher concentrations (IC50 = 1.0 and 1.6 M, respectively). Shown to reduce LPS-induced TNF- production in PBMCs (IC50 = 250 nM) and exhibit oral availability with good pharmacokinetic in rats in vivo.
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GHS Pictogram :
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GHS No : GHS07,GHS09
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Signal Word : Warning
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UN#: 3334
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Class : 9
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Packing Group : Ⅲ
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Hazard Statements : H227-H302-H315-H317-H411
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Precautionary Statements : P210-P261-P264-P270-P272-P273-P280-P302+P352-P330-P362+P364-P370+P378-P391-P403-P501
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Lot numbers can be found on the outside label of a product: