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Structure of 1000339-52-5
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3-Fluoro-2-nitrobenzonitrile features a fluorine atom ortho to a nitro group on a benzonitrile scaffold, creating a highly electron-deficient aromatic system. This combination enables efficient coupling reactions in synthetic workflows, particularly in transition-metal-catalyzed cross-couplings and nucleophilic aromatic substitutions. The molecule exhibits excellent stability under standard bench conditions and serves as a valuable building block for pharmaceutical intermediates and functionalized materials.
3-Fluoro-2-nitrobenzonitrile serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the ortho position relative to the nitrile group. Its dual electron-withdrawing substituents (nitro and cyano) enhance electrophilicity for nucleophilic aromatic substitution, while the fluorine atom facilitates subsequent cross-coupling reactions. The compound exhibits good bench stability and is compatible with standard purification methods, making it well-suited for use in multi-step syntheses of heterocyclic scaffolds and pharmaceutical intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: