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CS-W001157 4
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6-Chloro-1H-pyrrolo[3,2-c]pyridine-3-carbaldehyde

  • CAS No. 1000341-64-9

  • Cat. No. CS-0033952
  • Purity≥98%
  • MDL No.MFCD09749983
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

6-Chloro-1H-pyrrolo[3,2-c]pyridine-3-carbaldehyde|CS-0033952

Structure of 1000341-64-9

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Description

6-Chloro-1H-pyrrolo[3,2-c]pyridine-3-carbaldehyde features a rigid heteroaromatic core with a chlorinated pyrrolopyridine scaffold and a reactive aldehyde handle. This electron-deficient system enables direct coupling in cross-coupling reactions and facilitates incorporation into bioactive scaffolds. The aldehyde group offers site-specific functionalization under mild conditions, enhancing synthetic efficiency in medicinal chemistry workflows.

Application

6-Chloro-1H-pyrrolo[3,2-c]pyridine-3-carbaldehyde serves as a versatile building block for the synthesis of heterocyclic scaffolds in medicinal chemistry. The aldehyde functionality enables direct incorporation into Ugi-type reactions and reductive amination workflows, while the chloro substituent supports palladium-catalyzed cross-coupling transformations. Bench-stable and compatible with standard protecting group strategies, it facilitates efficient access to complex pyrrolopyridine-based API candidates.

General Information

  • CAS No. 1000341-64-9
  • Cat. No. CS-0033952
  • Purity ≥98%
  • MDL No. MFCD09749983
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅ClN₂O
  • Molecular Weight 180.59
  • Synonym(s) 6-Chloro-5-azaindole-3-carboaldehyde
  • SMILES O=CC1=CNC2=C1C=NC(Cl)=C2

Computational Chemistry Data

  • TPSA   45.75
  • LogP   2.0288
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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