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Structure of 1000342-95-9
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4-Bromo-6-(trifluoromethyl)-1H-indazole features a sterically hindered trifluoromethyl group and a bromine substituent at electron-deficient positions, enabling direct functionalization in cross-coupling reactions. This bench-stable heterocycle integrates readily into bioactive scaffolds requiring enhanced metabolic stability and lipophilic character.
4-Bromo-6-(trifluoromethyl)-1H-indazole serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions for the construction of biologically relevant heterocyclic scaffolds. The bromo group facilitates efficient C–C bond formation, while the trifluoromethyl moiety enhances metabolic stability and modulates electronic properties. This compound exhibits excellent bench stability and compatibility with standard synthetic protocols, making it well-suited for iterative synthesis and library generation in drug discovery workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: