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Structure of 1000343-13-4
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5-Bromo-6-methyl-1H-indole integrates a bromine substituent at C5 and a methyl group at C6, creating a sterically accessible, electron-deficient indole core. This configuration enables direct functionalization in cross-coupling reactions and facilitates incorporation into bioactive scaffolds requiring halogen-directed derivatization.
5-Bromo-6-methyl-1H-indole serves as a versatile building block in medicinal chemistry and heterocyclic synthesis, enabling direct functionalization at the C5 position via palladium-catalyzed cross-coupling reactions. Its methyl group enhances solubility and modulates electronic properties, while the bromine facilitates efficient derivatization under standard Suzuki-Miyaura and Stille conditions. The compound exhibits excellent bench stability and is readily purified by flash chromatography or recrystallization, making it well-suited for scale-up applications in API development and target-oriented synthesis.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: