4-Bromo-1-chloro-2-(difluoromethoxy)benzene

Name: 4-Bromo-1-chloro-2-(difluoromethoxy)benzene
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1000575-20-1
Cat. No. CS-0112694
Purity≥95%
MDL No.MFCD09878214

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Bromo-1-chloro-2-(difluoromethoxy)benzene|CS-0112694

Structure of 1000575-20-1

Size

Price

Quantity

* Please select Quantity before adding items.

Description

4-Bromo-1-chloro-2-(difluoromethoxy)benzene is a fluorinated aromatic building block featuring orthogonal halogen handles and a difluoromethoxy substituent. This configuration enables selective cross-coupling reactions under standard conditions, with the electron-withdrawing difluoromethoxy group enhancing reactivity in palladium-catalyzed transformations. The molecule exhibits bench-stable handling characteristics and compatibility with diverse synthetic workflows.

Application

4-Bromo-1-chloro-2-(difluoromethoxy)benzene serves as a versatile building block in medicinal chemistry and materials synthesis, enabling palladium-catalyzed cross-coupling reactions due to its complementary halogen reactivity. The difluoromethoxy group enhances metabolic stability and modulates lipophilicity, while the ortho-chloro substituent provides site-specific functionalization potential. Bench-stable and compatible with standard reaction conditions, it facilitates efficient access to complex aromatic scaffolds.

General Information

CAS No. 1000575-20-1
Cat. No. CS-0112694
Purity ≥95%
MDL No. MFCD09878214
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₄BrClF₂O
Molecular Weight 257.46
Synonym(s) 4-bromofurfural diethyl acetal
SMILES FC(F)OC1=CC(Br)=CC=C1Cl

Computational Chemistry Data

TPSA 9.23
LogP 3.7039
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 2

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Ether

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

1000575-20-1 sigma1000575-20-1 manufacturer1000575-20-1 price1000575-20-1 structure1000575-20-1 SDSbuy 1000575-20-11000575-20-1 supplier1000575-20-1 uses1000575-20-1 molecular weightprice of 1000575-20-11000575-20-1 chemical name formula of 1000575-20-1

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

4-Bromo-1-chloro-2-(difluoromethoxy)benzene

CAS No. 1000575-20-1

Recommended Products