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CS-W001157 4
Total: USD 88.00

(2-Methoxy-6-methylpyridin-3-yl)boronic acid

  • CAS No. 1000802-75-4

  • Cat. No. CS-0141362
  • Molecule weight166.97
  • Purity≥98%
  • MDL No.MFCD07374993

*For research and further manufacturing use only, not for direct human use.

(2-Methoxy-6-methylpyridin-3-yl)boronic acid|CS-0141362

Structure of 1000802-75-4

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General Information

  • CAS No. 1000802-75-4
  • Cat. No. CS-0141362
  • Purity ≥98%
  • MDL No. MFCD07374993
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₀BNO₃
  • Molecular Weight 166.97
  • Synonym(s) 2-Methoxy-6-methylpyridine-3-boronic acid
  • SMILES OB(C1=CC=C(C)N=C1OC)O

Description

This boronic acid features a methoxy-substituted pyridine core with methyl and boronic acid functionalities positioned for efficient cross-coupling. The electron-donating methoxy group enhances reactivity, while the ortho-methyl substituent provides steric control. Bench-stable under standard conditions, it integrates seamlessly into Suzuki-Miyaura coupling workflows for constructing complex heterocyclic architectures.

Application

(2-Methoxy-6-methylpyridin-3-yl)boronic acid serves as a versatile building block in palladium-catalyzed cross-coupling reactions, enabling efficient construction of biaryl and heteroaryl architectures. Its moderate steric profile and functional group tolerance facilitate reliable coupling with aryl halides and triflates under standard conditions. The methoxy and methyl substituents enhance solubility and stability, supporting straightforward handling and purification—ideal for iterative synthesis in medicinal chemistry and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   62.58
  • LogP   -0.92158
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   2

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